The Journal of Cellular Biochemistry publishes descriptions of original research in which complex cellular, pathogenic, clinical, or animal model systems are studied by biochemical, molecular, genetic, epigenetic or quantitative ultrastructural approaches. Submission of papers reporting genomic, proteomic, bioinformatics and systems biology approaches to identify and characterize parameters of biological control in a cellular context are encouraged. The areas covered include, but are not restricted to, conditions, agents, regulatory networks, or differentiation states that influence structure, cell cycle & growth control, structure-function relationships, cell fate and lineage commitment or assembly mechanisms in cells, viruses, or supramolecular constructs, and signaling mechanisms mediating transcription. This scope extends to cell structure and function; organelle assembly; regulation of cell organization, reproduction or differentiation; the architectural organization and compartmentalization of nucleic acids and regulatory proteins within the nucleus and cytoplasm; the dynamics of intranuclear trafficking, placement and assembly of regulatory machinery for gene expression; the development, organization or remodeling of tissues; and to stem cell biology and regenerative medicine.

《細胞生物化學雜志》發表了原始研究的描述，其中復雜的細胞、致病、臨床或動物模型系統通過生化、分子、遺傳學、表觀遺傳學或定量超微結構方法進行研究。鼓勵提交報告基因組學、蛋白質組學、生物信息學和系統生物學方法的論文，以便在細胞環境中識別和表征生物控制的參數。所涉及的領域包括但不限于影響結構、細胞周期和生長控制、結構-功能關系、細胞命運和譜系承諾或細胞、病毒或超分子結構中的裝配機制的條件、試劑、調控網絡或分化狀態，以及介導轉錄的信號機制。這個范圍擴展到細胞結構和功能;細胞器組裝;細胞組織、繁殖或分化的調節;核酸和調節蛋白在細胞核和細胞質內的結構組織和分隔;核內販運、基因表達調控機制的放置和組裝的動力學;組織的發育、組織或重塑;以及干細胞生物學和再生醫學。